Molecular Genetics
For a complete list of publications:
2018
Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene
Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.
Cell. 2018 Feb 8. pii: S0092-8674(18)30049-7.
2017
YY1 is a structural regulator of enhancer-promoter loops
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.
Cell. 2017 Dec 14;171(7):1573-1588.e28. Epub 2017 Dec 7.
A phase separation model for transcriptional control
Hnisz D*, Shrinivas K*, Young RA, Chakraborty A, Sharp PA.
Cell. 2017 Mar 23;169(1):13-23. *co-first author
New insights into genome structure: genes of a feather stick together
Hnisz D, Young RA.
Mol Cell. 2017 Sep 7;67(5):730-731.
Transcriptional addiction in cancer
Bradner JE, Hnisz D, Young RA.
Cell. 2017 Feb 9;168(4):629-643. Review.
Small genomic insertions form enhancers that misregulate oncogenes
Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA.
Nat Commun. 2017 Feb 9;8:14385.
2016
Insulated neighborhoods: structural and functional units of mammalian gene control
Hnisz D*$, Day DS*$, Young RA$.
Cell. 2016 Nov 17;167(5):1188-1200. Review. *co-first author, $corresponding author
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Clark VE, Harmancı AS, Bai H, Youngblood MW, Lee TI, Baranoski JF, Ercan-Sencicek AG, Abraham BJ, Weintraub AS, Hnisz D, Simon M, Krischek B, Erson-Omay EZ, Henegariu O, Carrión-Grant G, Mishra-Gorur K, Durán D, Goldmann JE, Schramm J, Goldbrunner R, Piepmeier JM, Vortmeyer AO, Günel JM, Bilgüvar K, Yasuno K, Young RA, Günel M.
Nat Genet. 2016 Oct;48(10):1253-9.
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.
Science. 2016 Mar 25;351(6280):1454-1458.
3D chromosome regulatory landscape of human pluripotent cells
Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.
Cell Stem Cell. 2016 Feb 4;18(2):262-75.
2015
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
Hnisz D*, Schuijers J*, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA.
Mol Cell. 2015 Apr 16;58(2):362-70. *co-first author
2014
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
Dowen JM*, Fan ZP*, Hnisz D*, Ren G*, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA.
Cell. 2014 Oct 9;159(2):374-387. *co-first author
2013
Super-enhancers in the control of cell identity and disease
Hnisz D*, Abraham BJ*, Lee TI*, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.
Cell. 2013 Nov 7;155(4):934-47. *co-first author
Master transcription factors and mediator establish super-enhancers at key cell identity genes
Whyte WA*, Orlando DA*, Hnisz D*, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.
Cell. 2013 Apr 11;153(2):307-19. *co-first author