2018

Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene

Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.

Cell. 2018 Feb 8. pii: S0092-8674(18)30049-7. 

2017

YY1 is a structural regulator of enhancer-promoter loops

Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.

Cell. 2017 Dec 14;171(7):1573-1588.e28. Epub 2017 Dec 7.

A phase separation model for transcriptional control

Hnisz D*, Shrinivas K*, Young RA, Chakraborty A, Sharp PA.

Cell.  2017 Mar 23;169(1):13-23.   *co-first author

New insights into genome structure: genes of a feather stick together

Hnisz D, Young RA.

Mol Cell. 2017 Sep 7;67(5):730-731.

Transcriptional addiction in cancer

Bradner JE, Hnisz D, Young RA.

Cell. 2017 Feb 9;168(4):629-643. Review.

Small genomic insertions form enhancers that misregulate oncogenes

Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA.

Nat Commun. 2017 Feb 9;8:14385.

Components of Gene Control Altered in Cancer (Bradner, Hnisz and Young, Cell 2017)

2016

Insulated neighborhoods: structural and functional units of mammalian gene control

Hnisz D*$, Day DS*$, Young RA$.

Cell. 2016 Nov 17;167(5):1188-1200. Review.  *co-first author, $corresponding author

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

Clark VE, Harmancı AS, Bai H, Youngblood MW, Lee TI, Baranoski JF, Ercan-Sencicek AG, Abraham BJ, Weintraub AS, Hnisz D, Simon M, Krischek B, Erson-Omay EZ, Henegariu O, Carrión-Grant G, Mishra-Gorur K, Durán D, Goldmann JE, Schramm J, Goldbrunner R, Piepmeier JM, Vortmeyer AO, Günel JM, Bilgüvar K, Yasuno K, Young RA, Günel M.

Nat Genet. 2016 Oct;48(10):1253-9.

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.

Science. 2016 Mar 25;351(6280):1454-1458.

3D chromosome regulatory landscape of human pluripotent cells

Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.

Cell Stem Cell. 2016 Feb 4;18(2):262-75.

2015

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

Hnisz D*, Schuijers J*, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA.

Mol Cell. 2015 Apr 16;58(2):362-70.    *co-first author

2014

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

Dowen JM*, Fan ZP*, Hnisz D*, Ren G*, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA.

Cell. 2014 Oct 9;159(2):374-387.    *co-first author

2013

Super-enhancers in the control of cell identity and disease

Hnisz D*, Abraham BJ*, Lee TI*, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.

Cell. 2013 Nov 7;155(4):934-47.    *co-first author

Master transcription factors and mediator establish super-enhancers at key cell identity genes

Whyte WA*, Orlando DA*, Hnisz D*, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.

Cell. 2013 Apr 11;153(2):307-19.    *co-first author